Ionian << eye OH nee uhn >> Sea is the deepest part of the Mediterranean Sea. It separates Italy and Sicily from Albania and Greece. The Strait of Otranto connects it with the Adriatic Sea. The Gulf of Corinth is the largest of many deep inlets formed by the Ionian Sea on the coast of Greece. The Ionian Islands lie in the eastern part of the sea. Its greatest width is about 420 miles (676 kilometers), and its greatest depth is 16,302 feet (5,093 meters). The sea was named after the Greek nymph Io, who supposedly wandered along its shores.